Table 2 Susceptibilities of M. abscessus strains to combinations of beta-lactams

From: Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection

  

CPTa

IMI

IMI

IMI

IMI

CFT

CFT

CFT

MER

CFT

MER

  

–

–

CFT (1)

AVI (4)

AVI (4)

AVI (4)

CAZ (100)

AVI (4)

VAB (8)

MER (1)

AVI (4)

Strain

R/Sb

–

–

–

–

CAZ (100)

–

–

CAZ (100)

–

VAB (8)

CAZ (100)

GD276

R/S

8c

1

0.5

1

0.5

0.5

0.5

0.25

4

8

1

GD276-2

S

32

8

4

2

2

4

0.5

0.25

4

8

1

GD276-1

R

32

8

4

4

0.5

1

0.5

0.25

4

8

1

  1. Antibiotic sensitivities are shown as minimum inhibitory (MIC100) concentrations (µg/ml).
  2. aAntibiotic abbreviations: CPT ceftaroline, IMI imipenem, MER meropenem, AVI avibactam, VAB vaborbactam, CAZ ceftazidime. Fixed concentrations of drugs are shown in parentheses in µg/ml.
  3. bR, S Rough and smooth colony morphotypes; R/S, mixed colony morphotypes
  4. cMinimum inhibitory concentration (MIC) values in µg/mls
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