Fig. 2: Structural similarity search identifies protein clusters.

A Graphical display of all structurally similar protein clusters. The 690 herpes proteins that passed the quality score were analyzed pairwise by Foldseek for structural similarity. The color scheme for the viral species is used throughout this work. The name of the protein is written in the center of each node and is legible upon zooming in https://www.herpesfolds.org/herpesclusters allows interactive browsing of the clusters. B Cluster of viral serine/threonine-protein kinases US3 and UL13. C Cluster of viral DNA helicase/primase complex-associated protein (HEPA) and DNA polymerase catalytic subunit (DPOL). D Clusters of small capsomere-interacting protein (SCP). The alpha-, beta-, and gammaherpesviruses clustered separately. The corresponding UCSF ChimeraX session can be found at https://zenodo.org/records/13284140.