Fig. 6: DP2 antagonism mediates airway remodeling resolution via enhanced IFN-γ. | Nature Communications

Fig. 6: DP2 antagonism mediates airway remodeling resolution via enhanced IFN-γ.

From: Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma

Fig. 6

Mice with CEA were inoculated with RV-1b mice and treated with vehicle or DP2 antagonist +/− anti-IFN-γ. Mice were euthanized at 7 dpi. Quantification of (A) ASM area and (B) collagen deposition and (C) Mucus score. (D) Lung TGF-β1 levels in homogenates. E Lung EGF levels in homogenates. F, G Number of CD86-expressing AM and CD206-expressing AMs in the lung. H Lung TNF levels. Data are presented as box-and-whisker plots showing individual data points with the boxes representing quartiles and whiskers indicating the range and are representative of two independent experiments showing similar results (n = 5–10 mice per group). Statistical significance between different groups was determined using one-way ANOVA with Dunnett’s multiple comparison test. * denotes p < 0.05; ** denotes p < 0.01 and *** denotes p < 0.001 compared to vehicle group. # denotes p < 0.05, ## denotes p < 0.01 and ### denotes p < 0.001 compared to DP2 antagonist-treated group. Source data are provided as a Source Data file.

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