Fig. 7: Proposed mechanism by which DP2 antagonism resolves ASM mass. | Nature Communications

Fig. 7: Proposed mechanism by which DP2 antagonism resolves ASM mass.

From: Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma

Fig. 7

Box A PGD2, EGF, and TGF-β1 are expressed at low levels in mice with stable chronic experimental asthma. Box (B) Upon a virus-associated exacerbation, PGD2 levels increase, elevating type-2 inflammation, TGF-β1 expression, and ASM remodeling. Box (C) DP2 antagonism ameliorates the aforementioned phenotypes via increased IFN-γ production by NK and CD8+ T cells. Box (D) By suppressing the production of endogenous PGD2, corticosteroids ablate the PGD2/DP1 receptor-induced IFN-γ expression that mediates the resolution of ASM remodeling. Created in BioRender. Howard, D. (2023) BioRender.com/c86z618.

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