Fig. 6: Large-scale phenotyping analysis of TKO mutants uncovers knockout and sex-specific phenotypes. | Nature Communications

Fig. 6: Large-scale phenotyping analysis of TKO mutants uncovers knockout and sex-specific phenotypes.

From: X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes

Fig. 6

a The German Mouse Clinic (GMC) phenotyping pipeline was conducted using 30 wildtype (WT, 15 males, 15 females) and 26 ∆Crossfirre-Firre-Dxz4 (TKO) mice (13 males, 13 females). The pipeline covered the screening tests from the following categories: immunology/allergy, behavior, biomarkers, cardiovascular, clinical chemistry, pathology, dysmorphology, eyes, metabolism, neurology, and nociception. b Visualization of key measured parameters to provide a general overview of the GMC screening pipeline results. The size of each triangle corresponds to the absolute effect size, represented by Cohen’s d. Triangles pointing up or down indicate upregulation or downregulation, respectively. Parameters with a p value < 0.05 are considered significant. N.S.: not significant (t-test). Additional parameter information, including p values, effect sizes (Cohen’s d, Hedges’ g), and parameter abbreviations are provided in Supplementary Data 1, sheets o–q. c Concise overview of the significant parameters as phenotypes for the groups TKO (n = 9), female-specific (n = 6), and male-specific (n = 13) by phenotyping category.

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