Fig. 5: MEC egocentric spatial representations are degraded in environments without physical walls.
From: Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex
a Representative firing patterns of egocentric and allocentric cells in an elevated platform without walls. (i) A center-bearing cell recorded across consecutive baseline (B), elevated platform (E), and second baseline (B’) sessions. (ii) Same as (i) but for a center-distance cell. (iii) Same as (i) but for a head-direction cell. Directional tuning curves have MVL values inset, and distance tuning curves have R2 of the center-distance - firing rate relationship inset. b Distribution of MVL values for 25 head-direction cells across sessions. All data are presented as mean values +/− SEM. Two-sided Wilcoxon signed-rank test, B-E, Z = -0.63, P = 0.53; E-B’, Z = -0.90, P = 0.37; B-B’, Z = -0.63, P = 0.53. c Same as b but for 51 center-bearing cells. Two-sided Wilcoxon signed-rank test, B-E, Z = -5.48, P < 0.001; E-B’, Z = -5.14, P < 0.001; B-B’, Z = -0.57, P = 0.57. d The change in MVL values for center-bearing cells between the first baseline session and elevated platform session. Black dots represent cells that still exhibit significant center-bearing selectivity on the elevated platform, while red dots represent cells that no longer reach our classification criteria. e Distribution of R2 values for 18 center-distance cells across sessions. Two-sided Wilcoxon signed-rank test, B-E, Z = -3.59, P < 0.001; E-B’, Z = -2.98, P = 0.003; B-B’, Z = -1.63, P = 0.10. Source data are provided as a Source Data file.
