Fig. 2: Association of plasma proteome modules with HIV status among 689 children, including 79 with HIV. | Nature Communications

Fig. 2: Association of plasma proteome modules with HIV status among 689 children, including 79 with HIV.

From: Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV

Fig. 2

A Forest plot of coefficient estimates showing association of plasma proteome modules measured at hospital discharge with HIV status. Estimates on the x-axis represent the beta-coefficients of this association. Points (centre of the bars) indicate beta coefficient estimates for every unit increase in plasma protein concentration in each module while error bars indicate 95% confidence interval. The red colour indicates significantly differentially expressed protein modules by HIV status. The size indicates the number of proteins in each module. B Eigenprotein adjacency heatmap showing the correlation between modules and HIV status, and superclusters. Purple coloured rectangle highlight HIV-related superclusters with eigenprotein correlations of ≥0.5. Superclusters only arising from HIV-related protein modules are highlighted. Abbreviations: PM, protein module, SC1 supercluster 1 comprised of modules 34, 17, and 30, SC2 supercluster 2 comprised of modules 19, 23 and 22, SC3 supercluster 3 comprised of modules 32, 33, and 12, SC4 supercluster 4 comprised of modules 25 and 10, SC5 supercluster 5 comprised of modules 7 and 8, SC6 supercluster 6 comprised of modules 37 and 31.

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