Fig. 3: Catalytic performance of the liquid−solid hybrid microreactors.
a Comparison of different catalytic systems in the kinetic resolution reaction of 1-phenylethyl alcohol, a1 schematic illustration of the different catalytic systems, a2–a4 Kinetic profiles for different catalytic systems: a2 hybrid microreactor based continuous-flow system; a3 conventional biphasic system; a4 hybrid microreactor system in batch, a5 comparison of the catalytic efficiency for different catalytic systems. b Impact of the different IL interior on the catalytic efficiency, including [PEGm(mim)2][NTf2]2 (m = 200, 600 or 1000) and [EMIM]NTf2, (b1, alcohol ee values with time; b2, their specific activity). c Specific activity of the hybrid microreactors with different IL interior at varied substrate concentrations. d Comparison of Km, Vmax, kcat and kcat /Km for CALB in the hybrid microreactor with different IL interior. e, f Comparison of the kinetic resolution of 4-methyl-2-pentanol or 1-(1-naphthyl)ethanol over the liquid−solid hybrid catalysts with different IL interior. (e1, f1: alcohol ee values with time; e2, f2: their specific activity). U is expressed as μmol of substrate converted per min (i.e. μmol min−1). Batch reaction conditions are included in the Experimental Section of Supporting Information. Continuous flow biocatalysis conditions: 3.0 g liquid−solid hybrid microreactor, alcohol substrate (0.1 M), vinyl acetate (0.4 M) in n-octane, 45 °C, flow velocity 2 mL h−1.
