Fig. 3: Spatial gene expression maps in PDAC and IPMN. | Nature Communications

Fig. 3: Spatial gene expression maps in PDAC and IPMN.

From: Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics

Fig. 3

A Spatial gene expression maps of S100P, MUC5AC, TFF1, CLDN4, ITGB6, INS and FAP in PDAC from multiple fields in a representative patient. The H&E slides in the first column illustrate the specific location of the spatial gene expression slice on the excised tissue. Yellow arrows indicate ducts. B Spatial gene expression levels of S100P, MUC5AC, TFF1, CLDN4, ITGB6, INS and FAP in IPMN (tissue samples from 3 patients). C IHC of MUC5AC and CLDN4 protein for four tissue samples (one PDAC and three IPMN). Spatial gene expression maps were based on a log-normalized gene counts using Seurat’s SCTransform function, and the scale bar represents the log-normalized counts. Representative histology and gene expression maps were based on a sample replicate of 12 separate regions from large biopsy samples from 4 individual patients.

Back to article page