Fig. 3: LPS-induced sepsis progression is attenuated in Cicf/f;Cd19-Cre and Atxn1lf/f;Cd19-Cre mice.
a–c Female Cd19-Cre and Cicf/f;Cd19-Cre mice were injected intravenously with LPS. Serum samples and lung tissues were collected from Cd19-Cre and Cicf/f;Cd19-Cre mice 12 h after LPS injection. a Survival rate of LPS-treated mice. Mortality was monitored every 24 h. N = 14 per group. b Serum IL-6 and IL-10 levels determined using ELISA. N = 4 per group. c Histology of immune cell infiltration into lung tissue. Arrows indicate immune cell-infiltrated regions. N = 3 per group. Scale bar: 100 µm. d–f Female Cd19-Cre and Atxn1lf/f;Cd19-Cre mice were injected intravenously with LPS. Serum samples and lung tissues were collected from Cd19-Cre and Atxn1lf/f;Cd19-Cre mice 12 h after LPS injection. d Survival rate of LPS-treated mice. Mortality was monitored every 24 h. N = 12 for Cd19-Cre and N = 13 for Atxn1lf/f;Cd19-Cre. e Serum IL-6 and IL-10 levels determined using ELISA. N = 3 per group. f Histology of immune cell infiltration into lung tissue. Arrows indicate immune cell-infiltrated regions. N = 4 for Cd19-Cre and N = 3 for Atxn1lf/f;Cd19-Cre. Scale bar: 100 µm. Data represent 2–3 independent experiments. Statistics: Log-rank (Mantel-Cox) test (a, d) and two-tailed Student’s t-test (b, c, e, f). Bar graphs present data as mean ± S.D. Ctrl: Cd19-Cre, Cic cKO: Cicf/f;Cd19-Cre, and A1L cKO: Atxn1lf/f;Cd19-Cre. LPS lipopolysaccharide, IL interleukin, and ELISA enzyme-linked immunosorbent assay. Source data are provided as a Source Data file.
