Fig. 8: The CIC-ATXN1L complex regulates B-2 cell development. | Nature Communications

Fig. 8: The CIC-ATXN1L complex regulates B-2 cell development.

From: The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression

Fig. 8

A schematic diagram illustrates the role of the CIC-ATXN1L complex in B-2 cell development. The left panel shows that CIC deficiency reduces the formation of FOB cells by downregulating BCR signaling. The specific CIC target genes involved in this process have not yet been identified. The right panel indicates that the deficiency of either CIC or ATXN1L downregulates NOTCH1 and NOTCH2 expression by de-repressing ETV4, leading to a decreased MZB cell population. The diagram was created using BioRender.com, which permits the reuse of its content under a CC-BY 4.0 Attribution 4.0 International license.

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