Scheme 1 | Nature Communications

Scheme 1

From: Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity

Scheme 1

Nanoparticles dynamically interact with immune cells via complement corona to exert antileukaemia efficacy. The interactions that occur at the IONPs-complement interface play a vital role in determining the immunological effects. IONP could adopt complement C3b, thereby bind to the C3 receptor (CR3) of the circulating monocytes. The activated circulating monocytes migrated to immune organs and differentiatied into resident macrophages, at the same time, IONPs-C3b complex potentiated the phagocytosis of leukaemia cells by resident macrophages. Furthermore, macrophages can present tumour antigens to T cells, subsequently activated adaptive antileukaemia immunity (Created in BioRender. Chen, F. (2023) https://BioRender.com/z95h917).

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