Fig. 6: Model for the activation of SLFN11 by DDAs and nuclear ssDNA.
From: Phosphorylation-mediated conformational change regulates human SLFN11
a SLFN11’s response to DNA-damaging agents, leading to an irreversible block of stalled replication forks, ribosome stalling, and cell death. b Regulation of SLFN11’s function as an immune sensor for nuclear ssDNA containing a CGT motif. The model was created based on our work26 and the work of other groups21,24,25,29.
