Fig. 7: Antibodies and disease mutations at the ECR/7TM interface change the distributions of ADGRL3 holoreceptor conformations. | Nature Communications

Fig. 7: Antibodies and disease mutations at the ECR/7TM interface change the distributions of ADGRL3 holoreceptor conformations.

From: Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Fig. 7

Schematic cartoon of the effects of sAB LK1 and cancer-associated mutations on conformational dynamics of ECR in ADGRL3. Activating sAB LK1 stabilizes the lower FRET states, while cancer mutants stabilize the higher FRET states of ADGRL3.

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