Fig. 3: MYC and MYCN copy number gains in A031201 cfDNA. | Nature Communications

Fig. 3: MYC and MYCN copy number gains in A031201 cfDNA.

From: AR alterations inform circulating tumor DNA detection in metastatic castration resistant prostate cancer patients

Fig. 3

a Relative MYC and MYCN gene copy number ratios in cfDNA specimens based on ctDNA aneuploidy fraction estimated by ichorCNA (samples below the ctDNA aneupoidy-high threshold of 0.142 are in gray/pink). A log2 ratio >= 0.3 is considered a gain. b UpSet plot showing co-occurrence of MYC and MYCN copy number gains in cfDNA samples from (a). c UpSet plot showing co-occurrence of MYC and MYCN copy number gains in mCRPC biopsy specimens from 444 patients analyzed in the AACR-PCF Stand Up To Cancer East Coast study. d UpSet plot showing co-occurrence of MYC and MYCN copy number gains in mCRPC biopsy specimens from 101 patients analyzed in the AACR-PCF Stand Up To Cancer West Coast study.

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