Fig. 5: Hepsin, Protein kinase C beta, and Integrin subunit beta 3 are associated with an increased risk of disease progression.

Forest plots indicating hazard ratios (HR) and 95% confidence intervals for proteins differentially expressed at 2 weeks and 1 month post estimated date of infection (EDI), relative to pre-infection levels (V1-V0 and V2-V0, respectively), as well as the difference between 2 weeks and 1 month post EDI (V2-V1). The Cox proportional hazards model was used to determine the association between plasma protein expression (independent variable) and the risk of disease progression. The event outcome was defined as CD4 + T-cell counts of 500 cells/µl from 6 weeks post the estimated date of infection. Covariates included age, sex, and cohort. Circles and triangles indicate depleted (depl) and neat plasma, respectively. Abbreviations: V0 visit 0 (collected before estimated date of infection), V1 visit 1 (collected 10–14 days post estimated date of infection), V2 visit 2 (collected 15–42 days before estimated date of infection), V1–V0 difference between visit V1 and V0, V2–V0 difference between visit V2 and V0, V2–V1 difference between visit V2 and V1. Source data are provided as a Source Data file.