Fig. 10: Anti-metastasis effect and antitumor immune response on E0771-bearing mice. | Nature Communications

Fig. 10: Anti-metastasis effect and antitumor immune response on E0771-bearing mice.

From: MMP-2-triggered, mitochondria-targeted PROTAC-PDT therapy of breast cancer and brain metastases inhibition

Fig. 10

a Bioluminescence imaging of mice bearing with brain-metastatic tumors. b Semi-quantification results of bioluminescence imaging on the 8th, 16th, and 24th post-tumor inoculation. c, d The ex vivo image and weights of primary tumors. e–g Percentages of CD80+ CD86+ DCs, CD8+ T cells, and CD4+ T cells in LNs. h–k Abundances of CD80+ CD86+ DCs, CD8+ T cells, CD4+ T cells, and Tcm cells in spleens. l–o Abundances of CD8+ T cells, PD-L1+ cells, Treg cells, and M1 cells in tumors. n = 9 mice per group for primary tumor growth and bioluminescence imaging studies in (a, b, d). n = 5 mice per group for other studies. All data are presented as mean ± SD. Two-tailed Student’s t test and One-way analysis of variance (ANOVA) with a Tukey post hoc test were used for the statistical comparison between the two groups and among multiple groups, respectively. A significant difference was considered when the p value was < 0.05. Source data are provided as a Source Data file.

Back to article page