Fig. 7: In vivo antitumor and anti-metastasis effects.

a Tumor volume of 4T1 tumor-bearing mice recording every 2 days (n = 6 mice). b Tumor weights of 4T1 breast cancer models (n = 6 mice). c Body weight of mice administrated with different formulations (n = 6 mice). d Ki67 and TUNEL staining assay of sectioned tumors (scale bar = 2 mm). e, f Ex vivo imaging and statistical results of lung metastases (n = 5 mice). g HE staining images of lung tissues (scale bar = 5 mm in HE images, scale bar = 100 μm in enlarged images). h, i Weights and ex vivo image of recurrent tumors (n = 5 mice). The G1–G8 represent Control, dBET6, Ce6 + L, CFMPD + L, dBET6@CFMPD, dBET6@CPD + L, BET6@CFPD + L, and BET6@CFMPD + L, respectively. All data are presented as mean ± SD. Two-tailed Student’s t test and One-way analysis of variance (ANOVA) with a Tukey post hoc test were used for the statistical comparison between the two groups and among multiple groups, respectively. A significant difference was considered when the p value was < 0.05. Source data are provided as a Source Data file.