Fig. 9: In vivo osteogenic, angiogenic and immune regulation performance in infectious cranial defects. | Nature Communications

Fig. 9: In vivo osteogenic, angiogenic and immune regulation performance in infectious cranial defects.

From: Biodegradable Janus sonozyme with continuous reactive oxygen species regulation for treating infected critical-sized bone defects

Fig. 9

a Micro-CT analysis and reconstruction results, scale bar: 2 cm, five independent experiments were repeated. b BV/TV analysis (p = 0.0028; p < 0.0001; p < 0.0001), n = 5 independent experiments per group, data are expressed as mean ± SD. **p < 0.01, ****p < 0.0001, two-tailed ANOVA. c Masson’s trichrome staining images. The black box shows the defective area. Scale bar: 2.5 mm (above figures); Scale bar: 500 μm (below figures), five independent experiments were repeated. d IHC results of OPN. The yellow box shows the defective area. Scale bar: 2.5 mm (above figures); Scale bar: 250 μm (below figures), five independent experiments were repeated. e IF results of OPN and RUNX2, scale bar: 50 μm, five independent experiments were repeated. f IF results of VEGFA and CD31, scale bar: 50 μm, five independent experiments were repeated. g IF results of iNOS and CD206, scale bar: 50 μm, five independent experiments were repeated.

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