Fig. 7: Antibodies with similar monovalent affinity to a shared epitope can display large differences in neutralisation potency because of differences in propensity for bivalent binding.
From: The molecular reach of antibodies crucially underpins their viral neutralisation capacity
A The experimental neutralisation and binding parameters of antibody 182 and 394. B Simulations of antibody 181 (blue) and 394 (red) binding after 60 min using their measured binding parameters (vertical dashed lines indicate IC50 binding potency). C Comparison of predicted binding potency and experimental neutralisation potency. Source data are provided as a Source Data file.
