Table 1 Differential expression of key regulators of innate immune signaling in ECs exposed to conditioned media from SARS-CoV-2 infected SMCs (CoV-2 SMC CM), SARS-CoV-2 infected PC (CoV-2 PC CM), or BA5.1 infected SMCs (BA5.1 SMC CM) compared to control ECs

From: SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection

 

CoV-2 SMC CM

CoV-2 PC CM

BA5.1 SMC CM

Gene Name

Log2FC

Adj. p value

Log2FC

Adj. p value

Log2FC

Adj. p value

MX1

7.46

2.6e-10

0.79

0.534

1.94

0.024

BST2

8.07

2.15e-21

-0.72

0.042

1.03

0.002

DDX58

3.03

1.5e-10

-0.69

0.19

-0.61

0.180

IRF7

3.11

3.43e-9

-0.43

0.207

0.14

0.683

ISG15

3.84

5.62e-12

-0.48

0.087

0.25

0.852

HELZ2

2.43

2.98e-14

1.05

0.044

2.10

2.55e-5

OAS1

4.78

0.008

0.94

0.709

0.97

0.766

EPS11

5.55

3.78e-10

0.39

0.735

0.16

0.706

LY6E

3.65

4.29e-13

-0.42

0.135

0.31

0.429

  1. Effect sizes were estimated using DESeq2, with (two-tailed) p-values computed using the Wald statistic. A full list of differentially expressed genes can be found in the source data file.
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