Fig. 3: Influence of GABA on Best2 function in the presence of GS. | Nature Communications

Fig. 3: Influence of GABA on Best2 function in the presence of GS.

From: Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment

Fig. 3

a, b The I-V relationships of Best2 co-expressed with GS in HEK293 cells at 1 μM [Ca2+]i in the absence (black) or presence (red) of 100 μM external GABA, when Cl− is the principal anion in both internal and external solutions (a) or glutamate is the principal anion in the external solution (b); n = 6–8 for each point; *p < 0.05 compared to no GABA, using two-tailed unpaired Student’s t test. c, d The same format as a, b, respectively, for the endogenous currents from human NPE cells; n = 5–6 for each point. All error bars in this figure represent s.e.m.

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