Fig. 5: PABA-bound Best2 and Best1 structures. | Nature Communications

Fig. 5: PABA-bound Best2 and Best1 structures.

From: Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment

Fig. 5

a Side view of PABA-bound Best2 with PABA molecule shown as blue sticks. Black box indicates region of focus in panel (b). b Close-up of the PABA binding site with hydrogen bonds depicted as dotted lines and interacting residue side chains labeled. c, d Top views of Best2 (from the extracellular side of the membrane) with PABA molecules shown as blue spheres, I76 as brown spheres, and F80/F84 as pink spheres in the fully open (c) and closed (d) states. e–h PABA-bound Best1 structures in the same format as a–d, respectively, except for (h) showing an intermediate state.

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