Fig. 6: Functional rescue of Best1 patient-derived mutations by PABA. | Nature Communications

Fig. 6: Functional rescue of Best1 patient-derived mutations by PABA.

From: Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment

Fig. 6

a–f The I-V relationships at 1 μM [Ca2+]i in HEK293 cells transiently expressing WT Best1 alone (black, untreated), or co-expressing WT Best1 and patient-derived A10T (a), R218H (b), L234P (c), A243T (d), Q293K (e) and D302A (f) mutants at a 1:4 ratio (red) without (solid) or with (open) the treatment of PABA; n = 6–8; *p < 0.05 compared to untreated WT cells, using two-tailed unpaired Student’s t test. All error bars in this figure represent s.e.m.

Back to article page