Fig. 1: Simultaneous resting-state functional connectivity (rsFC) mapping with functional optoacoustic imaging (fOA) and functional magnetic resonance imaging (fMRI) using the hybrid magnetic resonance optoacoustic tomography (MROT) platform.
a T1-weighted image, magnetic resonance angiography (MRA), and blood oxygen level-dependent (BOLD) signal time series. b Time-resolved oxygenated (HbO), deoxygenated (HbR), and total (HbT) hemoglobin concentrations rendered by the multispectral fOA imaging. c Coregistration and spatial normalization techniques further facilitate the parcellation of the multimodal data, delineating distinct anatomical and functional brain regions for comprehensive analysis. d The method enables investigations into the correlation of rsFC patterns derived by BOLD versus the different hemoglobin-related optoacoustic components through seed-based and voxel-based analysis methods.
