Fig. 1: Population structure and ancestry in 1534 global P. vivax isolates.

P. vivax isolates form distinct populations to sub-continental level. a Neighbour-Joining tree for 1534 isolates, constructed using a distance matrix based on 499,206 high-quality bi-allelic SNPs, and coloured based on sub-regional grouping. b Principal Component Analysis (PCA) plot of the 1534 isolates, with colours based on sub-regional groupings in (a). c ADMIXTURE inference of 10 ancestral populations (K = 10) in the global dataset, visualised by bar plot, coloured by K population grouping, and summarised as frequencies in (d). EAF East Africa, MSEA Maritime South-East Asia, OCE Oceania, SAM South America, SAS South Asia, SEA South-East Asia.