Fig. 2: K31 attenuates necrosis, oxidative stress, and inflammation in the skin of an EPP mouse model.
From: Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria
Fech-mut mice (male) were pretreated with K31 (100 mg/kg, po) for 40 min followed by light exposure (once daily for 5 days). a, b Histological analyses of the skin with hematoxylin and eosin (H&E) or Sirius Red staining. Scale bars, 50 μm. c The ratio of glutathione (GSH) to glutathione disulfide (GSSG) in the skin. GSH and GSSG were analyzed by UPLC- QTOFMS. ***P = 0.0004, **P = 0.0082. d, e Expression of interleukin 1β (Il-1β) and tumor necrosis factor α (Tnfα) in the skin. Il-1β and Tnfα were analyzed by qPCR. For the date in Fig. 2d, ****P < 0.0001, ***P = 0.0002; for the date in Fig. 2e, **P = 0.0093, **P = 0.0077. All data are expressed as mean ± SEM (n = 6 mice). One-way ANOVA with Tukey’s multiple comparisons tests were used for statistical analysis. Source data are provided as a Source Data file.
