Fig. 4: PLA supplementation activate stress-response transcription factors SKN-1 and ATFS-1. | Nature Communications

Fig. 4: PLA supplementation activate stress-response transcription factors SKN-1 and ATFS-1.

From: A microbiota-derived metabolite, 3-phenyllactic acid, prolongs healthspan by enhancing mitochondrial function and stress resilience via SKN-1/ATFS-1 in C. elegans

Fig. 4

a Comparing the transcriptomes of the PLA-treated worm with those treated with either skn-1 RNAi or atfs-1 RNAi via scatter plots and Venn diagrams suggests that SKN-1 and AFTS-1 are crucial players generating the effect of PLA supplementation at the transcriptional level. b Hypothesis of PLA-induced longevity. PLA elevates organismal HAI with SKN-1/ATFS-1-mediated mitochondrial activation and stress resilience.

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