Fig. 6: Interaction of the four mtAP2 proteins with the rRNA fragments.
From: Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine
a mtAP2-1 is found in the SSU and localized near the mRNA channel exit (mRNA path is depicted as a broken red line) where it interacts with SSUB and SSUD. b mtAP2-1 interacts with the 3’ of SSUD and with SSUB mostly through arginine residues. c mtAP2-3 protein is located at the central protuberance above the nascent peptide exit channel on the solvent side. mtAP2-3 interacts with the 3’ of RNA13, 3’ of RNA29 and 5’ end of RNA38. d Interactions are mediated by arginine residues of mtAP2-3 and the bases of RNA13, RNA29 and RNA38. e mtAP2-2 below the CP, near the NPC, interacts with 3’ and 5’ of LSUA and is enlaced by RNA11. f Interactions are mediated by arginine residues of mtAP2-2 and the bases of RNA11, and 3’ end of LSUA. g mtAP2-4 protein is located at the LSU intersubunit face and interacts with RNA3 and LSUA. h mtAP2-4 interacts primarily with LSUA through arginine and acidic residues that interact with bases of the LSUA. i−k RAP proteins (i) and HPR proteins (j, k) are found in the peripheral of Toxoplasma mitoribosome (gray surface).
