Fig. 1: AD is marked by systemic inflammation and neutrophil activation in peripheral blood. | Nature Communications

Fig. 1: AD is marked by systemic inflammation and neutrophil activation in peripheral blood.

From: Integrated multi-omics profiling reveals neutrophil extracellular traps potentiate Aortic dissection progression

Fig. 1

A Flow chart of sample collection and study design. B Volcano plot depicting the differentially expressed proteins between patients with AD (n = 30) and matched healthy counterparts (n = 30). C Gene set enrichment analysis illustrating the hallmark pathways enriched in the patients with AD, including leukocyte activation and chemotaxis, neutrophil migration, and inflammatory process. D GO enrichment analysis showing enrichment of protein-DNA subunit organization and complex assembly, nucleosome organization and assembly in peripheral blood from patients with AD. E KEGG analysis showcasing enrichment pathways related to neutrophil extracellular traps (NETs) formation, platelet activation and actin regulation in peripheral blood from patients with AD. A two-sided statistical significance was set at adjusted p < 0.05. AD: aortic dissection; GO: Gene ontology; KEGG: Kyoto encyclopedia of genes and genomes.

Back to article page