Fig. 4: Thalamic inactivation reduces bilateral S1BF functional connectivity.
From: Peripheral contributions to resting state brain dynamics
a Targeted inhibition of thalamic neural activity is achieved by injecting fluorescent muscimol (FM) via a cannula implanted into VPM (magenta). The image at right corresponds to the dashed rectangular area in the schematic at left and shows FM distribution (red) in a representative animal. Scale bar = 1 mm. b Average T2w signal increase observed following FM infusion. c Average map of functional connectivity to an S1BF seed region before (top) and after (bottom) FM infusion. Regression coefficients indicated for voxels with two-sided t test p ≤ 0.01 over n = 8 animals. d Mean homotopic S1BF regression coefficients before (dark blue) vs. after (magenta) FM infusion in n = 8 animals, showing a significant decrease with paired t test p = 0.019. e Correspondence between FM spread indicated by T2w signal change in ventroposterior thalamus and change in homotopic rsFC regression coefficient. The dashed line indicates linear regression fit with correlation coefficient R = – 0.78 (p = 0.023, n = 8 animals).
