Fig. 5: NIR-II fluorescence imaging of H2S in subcutaneous liver tumors.
From: NIR-II-excited off-on-off fluorescent nanoprobes for sensitive molecular imaging in vivo
a Schematic for NIR-II fluorescence imaging of H2S in HepG2 tumor-bearing mice. Created in BioRender. Jiajing, G. (2022) BioRender.com/m53h190. b NIR-II fluorescence imaging of tumors in mice at 5 min, 4, 8, and 12 h following intravenous injection (i.v.) injection of NDPs (2 mg Kg−1) in PBS, NDPs (2 mg Kg−1) with intratumoral injection (i.t.) injection of H2S enhancer (L-Cys) or scavenger (AOAA). (n = 3 mice per group). L-Cys (1 mM, 25 µL) or AOAA (1 mM, 25 µL) was injected into tumors at 4 h before i.v. injection of NDPs. Red arrows indicate the locations of HepG2 tumors in mice, and yellow circles indicate the locations of normal tissues. c A comparison of the T/N contrast ratio after the administration of L-Cys-NDPs, PBS-NDPs, and AOAA-NDPs (n = 3 biologically independent samples; mean ± SD). P < 0.0001. Statistical significance was determined using one-way ANOVA.
