Fig. 3: Substrate scope of biaryl skeletons, aryl, vinyl and natural product derived boronic esters. | Nature Communications

Fig. 3: Substrate scope of biaryl skeletons, aryl, vinyl and natural product derived boronic esters.

From: Asymmetric synthesis of atropisomers featuring cyclobutane boronic esters facilitated by ring-strained B-ate complexes

Fig. 3

a1 (0.40 mmol, 2.0 equiv.), 2 (0.40 mmol, 2.0 equiv.), 3 (0.20 mmol, 1.0 equiv.), Pd2(dba)3 (0.005 mmol, 2.5 mol%) and (Ra)-L7 (0.012 mmol, 6 mol%) in THF and toluene at 60 oC. Only cis-cyclobutane isomers were observed in this reaction unless otherwise noted. bUsing (Ra)-L6 in MeCN instead of toluene. cUsing 1 (0.60 mmol, 3.0 equiv.) and 2a (0.60 mmol, 3.0 equiv.). dReacting at toluene (0.6 mL) and MeCN (0.4 mL). eUsing (Ra)-L6 instead of (Ra)-L7. fUsing MeCN instead of toluene. gThe diastereoselectivity was determined by NMR analysis. hThe diastereoselectivity was determined by HPLC analysis. iUsing (Ra)-L8 in THF and DCM at 60 oC.

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