Fig. 5: CDS enriched for protein-altering mutations in colonising isolates of the extended dataset.

A The top 20 most significant CDS are labelled on the plot. Each circle denotes a single locus, whose size is proportional to the number of hosts mutations arose independently from. Loci are placed at the x-axis based on their chromosome coordinates. The y-axis shows their uncorrected p-value resulting from a single-tailed Poisson test comparing the density of mutations in CDS against the expected number of mutations, obtained from multiplying the genome-wide mutation count per bp by the CDS length (see Methods). The dotted horizontal line represents the genome-wide statistical significance threshold. B Locus id and annotation of statistically significant CDS (n = 11) only. Locus IDs in bold indicate the genes that became statistically significant in the extended dataset. The second column shows the number of mutations originating in different hosts. The p-value presented in this table corresponds to the Benjamini-Hochberg corrected p-value. Mutations identified in a collection of 7150 S. aureus isolate genomes from 1593 individuals (See Supplementary tables 1 and 8). Source data are provided as a Source Data file.