Fig. 4: Comparison of betas for lead variants identified from the discovery and replication cohort. | Nature Communications

Fig. 4: Comparison of betas for lead variants identified from the discovery and replication cohort.

From: Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology

Fig. 4

Comparison of betas expressed as change in standard deviation of mean RPS for lead variants identified from the discovery (UK Biobank, n = 37067) genome-wide association study (GWAS) with their corresponding betas in the replication (EPIC-Norfolk, n = 4273) analysis, with 95% confidence intervals. Betas in the cohort were calculated using a generalised linear mixed model, adjusting for age, sex and the first ten principal components. P-values are two-sided, calculated from the z-statistic and corrected for multiple comparisons. Variants meeting the Bonferroni-adjusted replication significance threshold (p = 0.05/ variants) in the EPIC-Norfolk GWAS are shaded black. The nearest gene is annotated for variants achieving genome-wide significance. Source data are provided as a Source Data file.

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