Fig. 1: Experimental workflow and clinical characteristics of cohort.

A Schematic of the experimental design to profile the characteristics of associated -omics with engraftment in HNSCC patient samples. Fragments of the same tumor were used for xenograft formation and molecular profiling. B Kaplan-Meier survival curve depicting the difference in disease-specific survival (DSS) between patients with engrafting (E) and non-engrafting (N) tumors. C Kaplan-Meier survival curve depicting the difference in DSS between patients within low (N^low) and high (N^high) N category risk groups. D Kaplan-Meier survival curve depicting the difference in DSS between the subsets of E and N patients across N category risk groups (different letters indicate FDR < 5% for pairwise comparisons, generalized linear hypothesis test (two-sided) on multivariate Cox model). E Clinical covariates for the cohort of HNSCC samples for which molecular data were collected. Unadjusted p-values are displayed from a two-sided log-rank test. Shaded boundaries represent 95% confidence interval estimates. Clinical data are provided in Supplementary Data Table 1.