Fig. 6: Molecular basis of CN cell type identity.
From: Molecular logic for cellular specializations that initiate the auditory parallel processing pathways
a Distribution of AUROC values of 5,735 GO terms across all 13 cell types in the snRNA-seq dataset. Red, AUROC ≥ 0.8. Right: GO term probability density by keywords: “synaptic”, “cell adhesion” and “ion channel” are skewed with AUROC ≥ 0.8. b AUROC value distribution of 1424 HGNC gene families across all 13 cell types. 104 families with AUROC ≥ 0.8 (red bars) are classified into seven categories (pie chart). See Supplementary Data 5 for more details. c Heatmap displays the z-scored expression levels of the top 10 specific TFs for each excitatory projection neuron type. TFs highlighted in red show expression in the developing cochlear nucleus, including progenitors and distinct developmental stages of projection neurons (see Supplementary Data 8 for reference support). d Heatmap showing the z-scored expression levels of the top 10 specific TFs for each inhibitory cell type. TFs in red have been shown to be involved in the differentiation and specification of glycinergic/GABAergic interneurons in cochlear nucleus or other brain regions (see Supplementary Data 8 for reference support). e Top-performing cell-adhesion molecule (CAM) families, their CAMAUROC value, and their roles in synaptic connectivity. “+” denotes the degree of involvement in the listed function. f Heatmap showing the differential expression of 9 CAM and 2 carbohydrate-modifying enzyme families across excitatory projection neuron types. g Heatmap showing the differential expression of 9 CAM and 2 carbohydrate-modifying enzyme families across inhibitory cell types.
