Fig. 1: Integration and repair mechanism of JHA and its application scope.
a Schematic illustration of the preparation procedures to construct JHA. b The process of SEIP to form JHA in situ: surface-immobilized GOx on the SL catalyze the blood glucose and O2 into gluconic acid and H2O2, which combined with ferrous glycinate (Fe[Gly]2) in the surface precursor to generate carbon radicals for initiating the interfacial radical polymerization, thus resulting in the fast generation of RL on the tissue surface; accompanied by the gelation process, the N-succinimidyl acrylate (AAc-NHS) in the RL precursor reacts with the amino groups on tissue surface, forming strong interfacial covalent bonding with the tissue, thereby enabling robust wet-adhesion and wound sealing. c The application of JHA for promoting POF wound healing by adhering JHA to tissue surfaces for sealing the penetrating wound and protecting it from mechanical stimuli and bacterial infection, relieving oxidative stress and creating a pro-healing microenvironment.
