Fig. 6: Analysis of the healing results of New Zealand rabbit POF models. | Nature Communications

Fig. 6: Analysis of the healing results of New Zealand rabbit POF models.

From: Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas

Fig. 6

a Schematic diagram of the process of applying JHA to New Zealand rabbit POF model. b Representative photographs of wounds with different treatments from day 0 to day 12. Scale bar: 1 cm. c Optical microscopy images of skin side tissue regeneration in POF defects stained with H&E. The dashed box areas are magnified and shown below (White dashed line: intact epithelial layer; red dashed line: defective epithelial layer; blue dashed line: inflammatory area). scale bars in both magnified images and insets: 300 μm. d Masson’s trichrome staining of the skin side. Scale bar: 300 μm. e Wound healing rate at different times. f Graded assessment of inflammation degree in each group. g Quantification results of collagen volume fractions of the skin side. Data are shown as mean ± s.d. (n = 5 New Zealand rabbits in e–g). One-way ANOVA followed by Tukey’s multiple comparison test was used for statistical analysis of (e, g).

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