Fig. 9: Sequencing analysis of the process of New Zealand rabbit POF repairing by JHA treatment. | Nature Communications

Fig. 9: Sequencing analysis of the process of New Zealand rabbit POF repairing by JHA treatment.

From: Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas

Fig. 9

a Heat maps of regenerated tissues between POF-only and JHA groups on day 4. b Top 20 genes in KEGG enrichment analysis of treated samples after mRNA sequencing between POF-only and JHA groups on day 4, including representative top 20 upregulated or downregulated pathways. c–e Fold change of gene expressing in cytokine-cytokine receptor interaction, JAK/STAT signaling pathway and IL-17 signaling pathway between POF-only and JHA groups on day 4. f Schematic of the JHA promoted POF healing by recruited macrophages, reduced neutrophils over enrichment, inhibited M1 macrophage polarization and suppressed ROS production.

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