Fig. 2: Pareto front of optimal dynamic control circuits.
From: Design principles for engineering bacteria to maximise chemical production from batch cultures
a Pareto fronts of optimal designs for each circuit topology shown. Schematics indicate the circuit topology of the dynamic control by TF and the dials indicate the enzymes whose constitutive expression was tuned. b Scatter plots of optimal values of three key parameters which suggest tuning to increase or decrease their values will shift circuit performance to achieve higher productivity but at a cost to yield, or higher yields at a cost to productivity.
