Fig. 2: The structure of T. brucei CBP110.
From: Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex
A T. brucei CBP110 is an α-helical protein with three consecutive domains: N-terminal (NTD), middle MIF4G-like, and C-terminal (CTD) domain. Cartoon representation with tubes representing α-helices. View similar to Fig. 1E, TbCBP20, and TbCBP30 models removed for clarity. TbCBP20 would be positioned in front of the view. B Human CBP80 (PDB: 1h2t35, with its three MIF4G-like domains has a similar shape and domain arrangement. C Comparison of TbCBP110 NTD and human CBP80 MIF4G-1 in topological coloring (N-terminus of the domain in blue to C-terminus of the domain in red); cartoon model of the domains and topological schematic. D Comparison of TbCBP110 CTD and human CBP80 MIF4G-3, as in (C). E Superposition of the TbCBP110 MIF4G-like domain (green) and human CBP80 MIF4G2 (blue). The domains superpose with an RMSD of 1.095 Å across 59 pruned atom pairs.
