Fig. 7: Surface plasmon resonance (SPR) sensorgrams of the apelin receptor NxStaR show loss of binding of truncated peptides and that the R/H1684.64 variant can still bind small molecule agonists. | Nature Communications

Fig. 7: Surface plasmon resonance (SPR) sensorgrams of the apelin receptor NxStaR show loss of binding of truncated peptides and that the R/H1684.64 variant can still bind small molecule agonists.

From: Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor

Fig. 7

a SPR sensorgrams of the apelin receptor NxStaR in the presence of endogenous apelin-13 peptide versus C-terminally truncated peptides (ΔC2-ΔC6). b SPR sensorgrams of apelin receptor NxStaR or the R/H1684.64 variant NxStaR in the presence of endogenous apelin-13 peptide (first column), the chimeric peptide NXE’992 (second column), the G protein biased, small molecule agonist CMF-019 (third column), and NXE’870 (fourth column) at pH 7.5 or 6.0. Source data are provided as a Source Data file.

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