Fig. 1: Dynamics of the Y chromosome-linked genome editor strategy.

a Schematic representation of a Y chromosome-linked genome editor construct (in blue) that generates dominant mutations in genes required for female survival/fertility (in red) in the male germline through nuclease activity. These mutations are detrimental when inherited by females (causing lethality or sterility) but do not affect males. Because the genetic construct is located on the Y chromosome, which is always inherited by males, all the males in the offspring inherit it, allowing this process to be maintained through generations. b Modelling of the transgene frequency in adult males (top) and relative number of adult females (bottom) in a target mosquito population upon a single male release equivalent to 50% of the initial male population for Sterile Insect Technique (SIT, orange), Release of Insects carrying a female-specific Dominant Lethal gene (fs-RIDL, red) and Y-linked editors (YLE, blue).