Fig. 6: Mapping of the loss-of-function or disease-related mutations in VANGL proteins. | Nature Communications

Fig. 6: Mapping of the loss-of-function or disease-related mutations in VANGL proteins.

From: Structural basis of human VANGL-PRICKLE interaction

Fig. 6

a The disease-related mutations in VANGL1 structure. Mutations that localize at the trimer interface are colored in green. Mutations that may affect the folding and structural stability of individual VANGL subunit are colored in red. Other mutations are colored in blue. b–d Zoom-in views of several disease-related mutations. e The loss-of-function and disease-related mutations in VANGL2. The color code is the same as that in (a). f, g Zoom-in views of several disease-related mutations.

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