Table 1 Excluded PSPRS Items and Rationale
Excluded PSPRS items | Rationale for exclusion |
|---|---|
Sleep difficulty Urinary incontinence | Not primary manifestations of PSP; may be downstream consequences or confounded by comorbidities |
Tremor Limb rigidity Irritability. Disorientation Emotional incontinence | Contributed little to disease progression or were least responsive to change over time |
Withdrawal Bradyphrenia | Cognitive or non-motor symptoms |
Finger tapping Toe tapping | Based on semi-quantitative neurological examination-based assessments that are not clinically meaningful to patients |
Apraxia of hand movement | High potential for variability in clinician ratings within and across patients |
Grasping | The change in patient ability to function associated with a change in score from absent to present is not assessed by the PSPRS |
