Fig. 2: Mice wih conditional deletion of Fam102a in osteoclasts exhibit an osteopetrotic phenotype.
From: Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation
a Representative micro-computed tomography (µCT) images of the distal femur in 12-week-old male Fam102aflox/Δ and CtskCre/+ Fam102aflox/Δ mice (scale bar, 1 mm). b New bone formation was determined by calcein double labeling (upper panel). TRAP staining of the proximal tibiae of 12-week-old male Fam102aflox/Δ and CtskCre/+ Fam102aflox/Δ mice (lower panel) (scale bar, 0.2 mm). c μCT analysis of the distal femur in 12-week-old male Fam102aflox/Δ and CtskCre/+ Fam102aflox/Δ mice (n = 5). d Bone morphometric analysis in the proximal tibiae in 12-week-old male Fam102aflox/Δ and CtskCre/+ Fam102aflox/Δ mice (n = 5). e In vitro osteoclast differentiation from Fam102aflox/Δ and CtskCre/+ Fam102aflox/Δ BMMs analyzed by TRAP staining (scale bar, 0.4 mm) (n = 5). Data are shown as the mean ± SEM. Statistical analyses were performed using unpaired two-sided Student’s t test. Source data are provided as a Source Data file.
