Fig. 5: Refined model for SFV neuroinvasion through the blood-CSF barrier.
From: VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
a Schematic presentation of the choroid plexus and the blood-CSF barrier. b Schematic presentation of VLDLR and ApoER2 expression in endothelial and epithelial cell layers and the effect knocking out Vldlr has on generalized SFV entry. Entry through the epithelial layer is solely mediated by VLDLR on the basolateral side, making Vldlr KO mice completely resistant to SFV neuroinvasion. Due to the strictly apical expression pattern, ApoER2 does not affect SFV passage through the epithelial cell layer from the basolateral side. Abbreviations: EC: endothelial cell, EpiC: epithelial cell, SFV: Semliki Forest virus, CSF: cerebrospinal fluid, WT: wild-type, KO: knock-out. Created in BioRender. Martikainen, M. (2024) https://BioRender.com/z30c241.
