Fig. 1: PTMNavigator combines PTM perturbation data, pathway diagrams, and enrichment analyses within a single application. | Nature Communications

Fig. 1: PTMNavigator combines PTM perturbation data, pathway diagrams, and enrichment analyses within a single application.

From: PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways

Fig. 1

A The four building blocks of PTMNavigator. Data from PTM perturbation experiments is provided by the user (top left). This data can then be projected onto canonical pathway diagrams from KEGG and WikiPathways (top right). Uploaded datasets are automatically processed using several enrichment analysis algorithms and the results are integrated into the visualization and displayed in tabular form (bottom left). The user also has the option to design custom pathways, either by using the canonical diagrams as templates or by starting from scratch (bottom right). Parts of the figure were created in BioRender53. B Overview of the enrichment algorithms available in PTMNavigator. *PHONEMeS is not an enrichment algorithm. Instead, it is a method to reconstruct pathways for phosphoproteomics datasets using prior knowledge.

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