Fig. 4: Analysis of a phosphoproteomic perturbation dataset in PTMNavigator. | Nature Communications

Fig. 4: Analysis of a phosphoproteomic perturbation dataset in PTMNavigator.

From: PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways

Fig. 4

A Edited screenshot from PTMNavigator showing an excerpt from the pathway diagram “mTOR Signaling Pathway - hsa04150” and the modified peptides significantly regulated by three of the drugs in Bekker-Jensen et al. Note that the authors added the node for EGFR. It is not part of the original pathway diagram but is known to interact with GRB2 and PI3K. The blue borders indicate kinases whose activity was significantly decreased (Score <−0.5, FDR < 0.1) according to KSEA analysis. Top: Lapatinib. Middle: Wortmannin. Bottom: Temsirolimus. B Edited screenshot from PTMNavigator showing an excerpt from the pathway diagram “MAPK signaling pathway - hsa04010” and the modified peptides regulated by two of the drugs in Bekker-Jensen et al. Regulated PTMs are colored by the size of the effect (Log2 Fold Change). Left: Cobimetinib. Right: Sorafenib. Source data are provided as a Source Data file.

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